Scroll below to browse our latest research publications.
Brazing techniques for the fabrication of biocompatible carbon-based electronic devices
Prototype electronic devices have been critical to the discovery and demonstration of the unique properties of new carbon composites. In this paper, we investigate the interplay of both chemical (“adhesive”) and mechanical (“cohesive”) forces at the interface of different forms of carbon.
Optimizing growth and post treatment of diamond for high capacitance neural interfaces
Here we report on a new high capacitance material fabricated using nitrogen included ultrananocrystalline diamond (N-UNCD). After exposure to oxygen plasma for 3 h, the activated N-UNCD exhibited high electrochemical capacitance. The in-vitro biocompatibility was then assessed and surface roughness was found to be critical for healthy neuron growth.
Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System
Soft, flexible electrodes demonstrate improved longevity, but pose a new challenge with regard to simple and accurate surgical implantation. We have developed a high aspect ratio water-soluble microneedle based on sucrose, permitting straightforward surgical implantation of soft, flexible microelectrodes.
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation remains an unresolved issue in epilepsy research. We found the transition to seizure to be a slow progression characterised by the loss of neuronal network resilience.
Deep Brain Stimulation for Epilepsy: Biomarkers for Optimization
This review presents the most recent clinical results with a focus on two major targets for deep brain stimulation (DBS), the anterior nucleus of the thalamus (ANT) and the hippocampus. We also detail evidence for the use of recorded neural responses in the optimisation of new technologies and treatments for epilepsy.
3D Diamond Electrode Array for High-Acuity Stimulation in Neural Tissue
In this work, we present a design of 3D nano-structured conductive diamond electrodes, integrated within a polycrystalline diamond housing. This design offers a high electrode density and count, which simultaneously satisfies spatial resolution and biocompatibility goals.
Hybrid diamond / carbon fiber microelectrodes enable multimodal electrical / chemical neural interfacing
Here, we present a method to deposit high surface area conducting diamond on carbon fibre microelectrodes. Such electrodes are needed for the next generation of miniaturized, closed-loop implants that can self tune by monitoring both electrophysiological and biochemical biomarkers.
Forecasting Cycles of Seizure Likelihood
Seizure cycles can be measured using a range of recording modalities, including self‐reported electronic seizure diaries. This study aimed to develop personalised forecasts from a mobile seizure diary app.
Critical slowing down as a biomarker for seizure susceptibility
In this paper, we test the hypothesis that markers of critical slowing down can be used as a biomarker of seizure susceptibility and that the auto- correlation and variance of the iEEG signals are modulated by patient-specific cycles over long temporal scales.
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